Abstract
A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes.
MeSH terms
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Acetates / administration & dosage
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Acetates / chemical synthesis
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Acetates / pharmacology*
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Administration, Oral
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Animals
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Blood Glucose / drug effects
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Cholesterol, HDL / blood
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Cholesterol, HDL / drug effects
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Drug Evaluation, Preclinical
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Ligands
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Mice
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Mice, Mutant Strains
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Mice, Obese
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Molecular Structure
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Oxazoles / chemistry*
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PPAR alpha / agonists*
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PPAR alpha / metabolism
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PPAR gamma / agonists*
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PPAR gamma / metabolism
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Structure-Activity Relationship
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Triglycerides / blood
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Triglycerides / metabolism
Substances
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Acetates
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Blood Glucose
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Cholesterol, HDL
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Ligands
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Oxazoles
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PPAR alpha
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PPAR gamma
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Triglycerides